Job Description
About the Company
Hillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue chip investors (Droia, Frazier, Novo, LifeArc).
Hillstar aspires to build a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and Systemic Lupus Erythematosus (SLE). CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). SLE on the other hand, affects an estimated 3 million adults worldwide, with symptoms affecting various organs including joints, kidneys, blood cells, brain, heart, and lungs. Existing treatment options for CAD and SLE have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, SLE, and potentially other serious autoimmune conditions with a common biological origin.
Job Description
Join Hillstar Bio as a strategic leader overseeing our CAD program. Take charge of defining program strategy, leading execution, and ensuring successful cross-functional collaboration. Manage a skilled team towards achieving our first IND milestone, crafting long-term life-cycle plans, and contributing to competitive intelligence.
This pivotal role offers a chance to shape our company culture, make a meaningful impact on patient care, and contribute to the growth of a pioneering organization. We seek a passionate, hands-on leader with a keen strategic mind and a collaborative spirit, ready to thrive in a dynamic, close-knit team environment.
Essential Duties and Responsibilities
Champion research efforts by designing and executing in vitro and in vivo experiments to investigate disease-causing mechanisms and generating proof-of-concept studies.
Development of in vitro and in vivo models of autoimmune diseases.
Biochemical and biological assay development (ELISA, flow cytometry, immunofluorescence)
Provide mentorship and scientific guidance to a team of scientists and external academic collaborations.
Manage vendors and CROs.
Assist in authoring technical reports and regulatory documents.
Accountable for the successful delivery of key program objectives.
Catalyze emerging scientific breakthroughs in precision immunology into new discovery programs.
Play a key team role in building and fostering Hillstar’s culture and contribute to its growth.
Collaborate on various aspects of general business and people operations, as needed.
Requirements
Qualifications
PhD in Immunology or related field.
A minimum of 10 years of experience in drug development, with a focus on autoimmune diseases.
Demonstrated experience in humoral and cell-mediated immunology, experience with B-cell depleting therapies is highly preferred.
Relevant experience is reflected by a track record of patents and high impact publications.
Self-motivated, collaborative, excellent time management and interpersonal skills.
Strong leadership skills with the ability to effectively lead and inspire a cross functional drug development team; demonstrated track-record of leading through influence as part of a strong and high-functioning team.
Experience with antibody development is a plus.
Strong scientific acumen, mechanistic understanding of pharmacology and disease biology, and exceptional learning agility.
Benefits
Hillstar Bio offers a competitive compensation and benefits package that includes unlimited vacation and market-leading parental leave.
Additional Information
This is a full-time position located in our Boston, MA office. Hillstar is committed to creating a diverse work culture and we are seeking individuals of all backgrounds, orientations, and identities. We are an equal opportunity employer and do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Job Tags
Permanent employment, Full time, Worldwide,